Spend a vacation in Venice or a summer in Santorini, Greece, and it might have been all the rage once upon a time. And if you want to really stump your travel agent, what about a jaunt up Mount Kilimanjaro, a hike through Machu Picchu, a visit to Easter Island or even a flight into outer space.

These secluded destinations, and a handful of others, have increasingly come into vogue in recent years. They are difficult and expensive to reach - think multiday plane journeys through third world countries. And sometimes they are uncomfortable upon arrival - acute mountain sickness is a common barrier to ascending Mount Kilimanjaro, for instance. In addition, many aren’t home to five-star hotels and world-class restaurants. But the world's farthest corners are attracting travelers determined to get a new perspective on the globe.

There are plenty of places right here on planet Earth that attract travelers determined to see something new and willing to pay for the privilege. Tour agents are clamoring to meet this demand, offering luxury tours of destinations from Africa to Antarctica.

In case the travelers to the world's most remote locales are likely to come home richer in mind and experience, they'll be significantly poorer in other ways. Two weeks in Antarctica and the Falkland Islands may cost you about $9,000 per person, not including airfare, and eight-day Galapagos Island tour is $3,000. A week rail tour of Mexico's Copper Canyon, a stunning series of gorges near the Sierra Madre mountains, may be of $4,000.

Here is a list of 10 tough-to-reach locales and outlined the standard itinerary for travel from New York City to each.